Panobinostat

설명

Panobinostat · CAS 404950-80-7 · C21H23N3O2. UNII 9647FM7Y3Z.

식별 정보

계산된 디스크립터

GHS 위험 분류

문헌상 용도

• Panobinostat is indicated in the treatment of multiple myeloma in combination with dexamethasone and bortezomib in patients who have received 2 previous treatment regimens including bortezomib and an immunomodulatory agent. This indication is approved by accelerated approval based on progression free survival as of February 23, 2015.
• Panobinostat is an oral histone deacetylase inhibitor and antineoplastic agent that is approved for use in combination with other agents in refractory or relapsed multiple myeloma. Panobinostat is associated with modest rate of minor serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent liver injury.
• Panobinostat is a drug that was previously approved by the U.S. Food and Drug Administration (FDA) under the brand name Farydak for the treatment of a certain type of cancer and is now no longer marketed in the United States. Panobinostat has been studied as an investigational drug as part of a strategy to cure HIV. As an investigational HIV therapy, panobinostat belongs to a group of drugs called latency-reversing agents.
• Avoid grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of panobinostat.
• Exercise caution with St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce the serum concentration of panobinostat.
• Take at the same time every day.

동의어

Panobinostat; 404950-80-7; LBH-589; Faridak; LBH 589; NVP-LBH589; 9647FM7Y3Z; (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide; CHEBI:85990; DTXSID40193506; 2-Propenamide, N-hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)-, (2E)-; 2-Propenamide, N-hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino) methyl)phenyl)-, (2E)-; 2-Propenamide, N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-; Panobinostatum; (E)-N-hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)prop-2-enamide

자주 묻는 질문

Panobinostat의 CAS 등록번호와 분자식은 무엇입니까?

CAS 404950-80-7; 분자식 C21H23N3O2; 분자량 — g/mol.

Panobinostat은(는) 다른 어떤 이름으로 알려져 있습니까?

Panobinostat, 404950-80-7, LBH-589, Faridak, LBH 589, NVP-LBH589.

Panobinostat은(는) 위험물로 분류됩니까?

보고된 위험 문구: H301, H331, H315, H318, H360.

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